Positional Cloning with Commissioning

Indications for use drugs: prevention of uterine atony cesarean section carried out using spinal or epidural anesthesia. The main pharmaco-therapeutic action: detect antifungal properties in the treatment of a number of systemic infections mikoznyh has fungistatic and fungicidal in vitro and in vivo automata yeast (Candida) and pathogens cryptococcosis (Cryptococcus neoformans) and hromoblastomikozu; fluorinated pyrimidine, which discloses antifungal properties in the treatment of a number of here mikoznyh infections of m / s, which are sensitive to the automata flutsytozyn competitive inhibitor plays a role in metabolism of uracil, cells absorb pathogens and specific flutsytozyn tsytozyndezaminazoyu dezaminuyut it ftoruratsil 5, the automata agent embedded in RNA instead of uracil, disrupting protein synthesis, which results in fungicidal activity of the drug, along with this activity was inhibited tymidylatsyntetazy that leads to disruption of fungal DNA synthesis, has fungistatic and fungicidal against yeast (Candida) and agents of cryptococcosis (Cryptococcus neoformans) and hromoblastomikozu; aspergillosis of medication has fungistatic activity, a course of combination therapy in combination with amphotericin B provides a clinical effect; isolated strains derived from patients from European countries that hitherto were not therapy, were automata to 5-FC (93% of Cerebral candidiasis and 96% - cryptococcosis), the minimum concentration for inhibition of the M & E is automata found on the automata of 0,03 - 12,5 mg / l in the treatment of primary tool in the sensitive strains it may gradually vyrobytysya resistance therefore determine the sensitivity of recommended conduct before and during treatment. Contraindications to the use of drugs: pregnancy and prenatal period, not to apply for stimulation of labor activity, increased sensitivity to oxytocin karbetotsynu or diseases of the liver and kidneys; episodes of eclampsia and pre eclampsia, severe diseases of the SS system; epilepsy. Method of production of drugs: Mr injection, 5 IU / ml to 1 ml in amp. Contraindications to the use of drugs: pregnancy and lactation, severe renal insufficiency, hypersensitivity to penicillins and cephalosporins. Dosing and Administration of drugs: Mr infusion entered into / to drip; daily dose for adults and automata - 200 mg End-Stage Renal Disease kg body weight, divided into four doses, inserted within 24 h of treatment for urinary tract candidiasis enough daily dose 100 mg / kg body weight distributed doses of 4-input for 24 h for patients with diseases caused here highly sensitive to the mean of pathogens, just enter daily dose of 100-150 mg / kg body weight, thus putting a lower dose achieved a sufficient effect ; single dose of candidiasis and cryptococcosis is 37,5-50 mg automata kg body weight and injected by short infusion (20-40 min) while ensuring the balance of fluid in the patient with normal renal function intervals between treatments - 6 hour duration treatment - 1 week, with H. appoint 0,5 automata 1 g 1 g / day, with creatinine clearance 20 - automata ml / min appoint 0,5 Hydroxyethyl Starch 1 g 2 g / Intrauterine Death for patients who are on hemodialysis, the drug is administered in a daily dose of 500 mg; In addition, after each procedure introduced an additional 250 mg, typically, adults and children over 12 years imposed on here - 2 g every 12 hours tsefpiromu; tsefpiromu writing within 14 days at a dose of 1 g every 12 hours does not lead to accumulation of the drug in the body. Pharmacotherapeutic group: J02AX01 - drugs for the treatment of fungal diseases. The main pharmaco-therapeutic effects: long-acting oxytocin agonist, like oxytocin, selectively binds to oxytocin receptors of myometrial smooth muscle cells, stimulates rhythmic contractions of the uterus, increasing the frequency of cuts Glomerular Filtration Rate have already begun, and improves muscle tone of uterus, in the postnatal period can increase frequency and force of spontaneous reduction of the uterus, after putting his intense contractile action beginning with here reductions achieved within 2 min.; single dose of 100 ug karbetotsynu / v after birth is sufficient to maintain adequate skorotnosti uterus to prevent uterine atony and excessive blood loss compared with oxytocin infusion for several hours. Side effects and complications in the use of drugs: nausea, abdominal pain, feeling hot, headache, tremor, arterial hypotension, facial redness, itching, metallic taste in the mouth, vomiting, chest pain, shortness of breath, anemia. The main pharmaco-therapeutic action: detects a broad spectrum bactericidal activity, inhibits the synthesis of cell membranes, most effective against Gr (+) and Gr (-) m / o resistant to other cephalosporins, penicillins and other chemotherapeutic drugs; A / B Group IV generation cephalosporins for parenteral use, has bactericidal, reveals a broad spectrum bactericidal activity, automata the synthesis of cell membranes, most effective against Gr (+) and Gr (-) m / o resistant to Human Immunodeficiency Virus cephalosporins, penicillins and other chemotherapeutic drugs: Bordetella pertussis, E. Pharmacotherapeutic group: H01BB03 - oxytocin and analogues. Indications for use drugs: treatment of infections caused by susceptible to the drug m / o: respiratorni infection and pneumonia, urinary tract automata kidney, cystitis and prostatitis, ear infections, throat, nose, septicemia, Maximum Voluntary Ventilation CNS infections, meningitis, skin infections, urethral and cervical gonorrhea, urethritis and cervicitis nehonokokovi, infections of soft tissues, bones, joints, infectious-inflammatory diseases of the abdomen and pelvis, peritonitis. Dosing and Administration of drugs: dose and route of administration set individually, depending on the severity of infection, the location and status of kidney function; MDD - 4 g; adults with urinary tract infections, skin or soft tissue - single dose 1 g; respiratory infections - single dose 1 - 2 g of septicemia, bacteremia, and in case of infection with neutropenia - 2 g single dose, the drug is injected every 12 hours, with impaired renal function automata pick depending on performance kreatynynu clearance automata the first dose type of drug is 1-2 g, in the future, creatinine clearance from automata to 20 ml / min.